Jack 3 November 2015, 4: The tiny red and white spheres show where sialic acid would be bound, in a pocket at the top of the HA.how virus replicate within host cell
It very helpful! Sakaaru 12 July 2012, 2: Dnhamil 26 January 2012, 1: Hello Prof. JJackson 13 December 2009, 11: The sialic acids bound by influenza viruses are attached to proteins. Every virus has a specific receptor that it attaches to, and in turn there is a particular viral protein that binds this cell receptor. Ha-tag 4 August 2010, 4: The glycoprotein underlying the sialyl glycans must be an endocytic protein, right?
How does it get in — or more accurately, how do the viral RNAs get into the cell? On the right is the chemical structure of sialic acid; the next sugar, to the right, is galactose.
On both occasions you have a virion adjacent to cell what is the difference why is there a net benefit to having NA cleaving sialic resisdues? I have fixed the image. A few examples: This is very interesting.
The globular top of the HA is at the top of the image. So good luck to everyone.
So what is the function of sialic acid apart from allowing virus infection — is it useful to us, or just an accident? Previous post: Comments on this entry are closed.
Hi Prof. Has there been any success to developing compounds that can out compete the HA ligand? David 8 August 2010, 10: Dear Prof, after reading this I came to have more questions about the process.
How does the virus prevent its NAs from removing the residues it needs to bind onto the glycocaylx before fusion?