Thus reduced levels of thrombomodulin will result in increased levels of free thrombin promoting coagulation and in reduced levels of protein C also promoting coagulation. Sign up using Facebook.
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By what mechanism does elevated homocysteine level accelerate thrombin formation? Sign up or log in Sign up using Google.Blood Clot Formation - Coagulation Factors & Platelets
Email Required, but never shown. Sign up using Email and Password. Lentz,SR and Sadler, JE 1991 Inhibition of thrombomodulin surface expression and protein-c activation by the thrombogenic agent homocysteine.
By inhibiting both thrombomodulin surface expression and protein C activation, homocysteine may contribute to the development of thrombosis in patients with cystathionine beta-synthase deficiency.
Abstract Elevated levels of plasma homocysteine are associated with both venous and arterial thrombosis. Linked 2. Protein C has an anticoagulant effect. Home Questions Tags Users Unanswered. Addition of 5 mM homocysteine to endothelial cells produced slight increases in thrombomodulin mRNA and thrombomodulin synthesis without affecting cell viability.
Upcoming Events. According to a heavily-cited paper below , homocysteine reduces the expression of thrombomodulin on the surface of endothelial cells.
Related 2. Homocysteine inhibits the function of thrombomodulin, an anticoagulant glycoprotein on the endothelial surface that serves as a cofactor for the activation of protein C by thrombin. Thrombomodulin binds to thrombin, and the resulting complex does not promote coagulation, but instead activates protein C. I haven't found any evidence that homocysteine has an effect upon thrombin formation directly.
Ask Question. In both cell types, thrombomodulin synthesized in the presence of homocysteine remained sensitive to digestion with endoglycosidase H and failed to appear on the cell surface, suggesting impaired transit along the secretory pathway.