How homocysteine causes thrombosis and haemostasis

how homocysteine causes thrombosis and haemostasis

Thus reduced levels of thrombomodulin will result in increased levels of free thrombin promoting coagulation and in reduced levels of protein C also promoting coagulation. Sign up using Facebook.

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how homocysteine causes thrombosis and haemostasis

By what mechanism does elevated homocysteine level accelerate thrombin formation? Sign up or log in Sign up using Google.

Blood Clot Formation - Coagulation Factors & Platelets

Post Your Answer Discard By clicking "Post Your Answer", you acknowledge that you have read our updated terms of service , privacy policy and cookie policy , and that your continued use of the website is subject to these policies. By what mechanism does this happen?

how homocysteine causes thrombosis and haemostasis

Email Required, but never shown. Sign up using Email and Password. Lentz,SR and Sadler, JE 1991 Inhibition of thrombomodulin surface expression and protein-c activation by the thrombogenic agent homocysteine.

By inhibiting both thrombomodulin surface expression and protein C activation, homocysteine may contribute to the development of thrombosis in patients with cystathionine beta-synthase deficiency.

It has been stated that elevated homocysteine level accelerates thrombin formation. The effects of homocysteine on thrombomodulin expression and protein C activation were investigated in cultured human umbilical vein endothelial cells and CV-1 18A cells that express recombinant human thrombomodulin. Biology Stack Exchange works best with JavaScript enabled. Hot Network Questions.

how homocysteine causes thrombosis and haemostasis

Abstract Elevated levels of plasma homocysteine are associated with both venous and arterial thrombosis. Linked 2. Protein C has an anticoagulant effect. Home Questions Tags Users Unanswered. Addition of 5 mM homocysteine to endothelial cells produced slight increases in thrombomodulin mRNA and thrombomodulin synthesis without affecting cell viability.

Upcoming Events. According to a heavily-cited paper below , homocysteine reduces the expression of thrombomodulin on the surface of endothelial cells.

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Related 2. Homocysteine inhibits the function of thrombomodulin, an anticoagulant glycoprotein on the endothelial surface that serves as a cofactor for the activation of protein C by thrombin. Thrombomodulin binds to thrombin, and the resulting complex does not promote coagulation, but instead activates protein C. I haven't found any evidence that homocysteine has an effect upon thrombin formation directly.

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Ask Question. In both cell types, thrombomodulin synthesized in the presence of homocysteine remained sensitive to digestion with endoglycosidase H and failed to appear on the cell surface, suggesting impaired transit along the secretory pathway.

how homocysteine causes thrombosis and haemostasis